NEUROCOGNITIVE ALTERATIONS AND PSYCHOSIS CAUSED BY MARIJUANA USE: A LITERATURE REVIEW
DOI:
https://doi.org/10.24980/ucm.v13i15.6161Keywords:
cannabis, psychosis, neurological alterations, cognitive alterationsAbstract
Cannabis is used by almost 190 million people in the world on an annual basis. The large increase in consumption reveals the need to understand the risks of psychiatric symptoms, especially psychotic ones, as well as explanations of the component of cannabis, delta-9-tetrahydrocannabinol (THC), involved in the problem. The research method used was a bibliographic review through the analysis of six articles obtained from electronic databases obtained from secondary sources - PubMed and Google Scholar. Articles were selected that provided a more in-depth understanding of the influence of cannabis use on psychiatric and behavioral changes.
References
BARRONA, J. I. B. Psicose e consumo de canábis: causa, consequência ou coincidência? 2017. 44f. Dissertação (Mestrado Integrado em Medicina) - Faculdade de Medicina, Universidade de Lisboa, 2017. Disponível em: http://hdl.handle.net/10451/31720.
BECKER, M. P. et al. Longitudinal changes in cognition in young adult cannabis users. Journal of Clinical and Experimental Neuropsychology, v. 40, n. 6, p. 529-543, 2017. Disponível em: https://doi.org/10.1080/13803395.2017.1385729. DOI: https://doi.org/10.1080/13803395.2017.1385729
BORGAN, F. et al. In Vivo Availability of Cannabinoid 1 Receptor Levels in Patients With First-Episode Psychosis. JAMA Psychiatry, v. 76, n. 10, p. 1074-1084, 2019. Disponível em: https://doi.org/10.1001/jamapsychiatry.2019.1427. DOI: https://doi.org/10.1001/jamapsychiatry.2019.1427
BORGAN, F. et al. The neural and molecular basis of working memory function in psychosis: a multimodal PET-fMRI study. Molecular Psychiatry, v. 26, n. 8, p. 4464-4474, 2021. Disponível em: https://doi.org/10.1038/s41380-019-0619-6. DOI: https://doi.org/10.1038/s41380-019-0619-6
BOSSONG, M. G. et al. Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum. Neuropsychopharmacology, v. 34, n. 3, p. 759-66, 2009. Disponível em: https://doi.org/10.1038/npp.2008.138. DOI: https://doi.org/10.1038/npp.2008.138
CHAVES, A. C. Primeiro episódio psicótico: uma janela de oportunidade para tratamento? Archives of Clinical Psychiatry, v. 34, n. supp. 2, p. 174–178, 2007. Disponível em: https://doi.org/10.1590/S0101-60832007000800005. DOI: https://doi.org/10.1590/S0101-60832007000800005
COLIZZI, M.; TOSATO, S.; RUGGERI, M. Cannabis and Cognition: Connecting the Dots towards the Understanding of the Relationship. Brain Sciences, v. 10, n. 3, 133, p. 1-4, 2020. Disponível em: https://doi.org/10.3390/brainsci10030133. DOI: https://doi.org/10.3390/brainsci10030133
DI FORTI, M. et al. The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study. The lancet. Psychiatry, v. 6, n. 5, p. 427-436, 2019. Disponível em: https://doi.org/10.1016/s2215-0366(19)30048-3. DOI: https://doi.org/10.1016/S2215-0366(19)30048-3
FERDINAND, R. F. et al. Cannabis use predicts future psychotic symptoms, and vice versa. Addiction, v. 100, n. 5, p. 612-618, 2005. Disponível em: https://doi.org/10.1111/j.1360-0443.2005.01070.x. DOI: https://doi.org/10.1111/j.1360-0443.2005.01070.x
GONZALEZ, R. et al. Performance of young adult cannabis users on neurocognitive measures of impulsive behavior and their relationship to symptoms of cannabis use disorders. Journal of Clinical and Experimental Neuropsychology, v. 34, n. 9, p. 962-76, 2012. Disponível em: https://doi.org/10.1080/13803395.2012.703642. DOI: https://doi.org/10.1080/13803395.2012.703642
HAYATBAKHSH, M. R. et al. Cannabis and anxiety and depression in young adults: a large prospective study. Journal of the American Academy of Child and Adolescent Psychiatry, v. 46, n. 3, p. 408-417, 2007. Disponível em: https://doi.org/10.1097/chi.0b013e31802dc54d. DOI: https://doi.org/10.1097/chi.0b013e31802dc54d
HINDLEY, G. et al. Psychiatric symptoms caused by cannabis constituents: a systematic review and meta-analysis. The Lancet Psychiatry, v. 7, n. 4, p. 344-353, 2020. Disponível em: https://doi.org/10.1016/s2215-0366(20)30074-2. DOI: https://doi.org/10.1016/S2215-0366(20)30074-2
HIRVONEN, J. et al. Decreased Cannabinoid CB1 Receptors in Male Tobacco Smokers Examined With Positron Emission Tomography. Biological Psychiatry, v. 84, n. 10, p. 715-721, 2018. Disponível em: https://doi.org/10.1016/j.biopsych.2018.07.009. DOI: https://doi.org/10.1016/j.biopsych.2018.07.009
INFANTE, M. A. et al. Neuropsychological Trajectories Associated with Adolescent Alcohol and Cannabis Use: A Prospective 14-Year Study. Journal of the International Neuropsychological Society, v. 26, n. 5, p 480-491, 2020. Disponível em: https://doi.org/10.1017/S1355617719001395. DOI: https://doi.org/10.1017/S1355617719001395
MARTIN-SANTOS, R. et al. Acute effects of a single, oral dose of d9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration in healthy volunteers. Current Pharmaceutical Design, v. 18, n. 32, p. 4966-4979, 2012. Disponível em: https://doi.org/10.2174/138161212802884780. DOI: https://doi.org/10.2174/138161212802884780
MEIER, M. H. et al. Associations between adolescent cannabis use and neuropsychological decline: a longitudinal co-twin control study. Addiction, v. 113, n. 2, p. 257-265, 2018. Disponível em: https://doi.org/10.1111/add.13946. DOI: https://doi.org/10.1111/add.13946
MOREAU, J. J. Hashish and mental illness [Internet]. New York: Raven Press; 1973. Disponível em: https://archive.org/details/hashishmentalill0000unse.
MOREIRA, E. C. Psicose e drogas: estado mental de risco e primeiro episódio psicótico em usuários de maconha [Internet]. EDUFBA; 2022. Disponível em: https://doi.org/10.7476/9786556305059. DOI: https://doi.org/10.7476/9786556305059
MURRAY, R. M. et al. What can we learn about schizophrenia from studying the human model, drug-induced psychosis?. American journal of medical genetics. Part B: Neuropsychiatric Genetics. v. 162 B, n. 7, p. 661-770, 2013. Disponível em: https://doi.org/10.1002/ajmg.b.32177. DOI: https://doi.org/10.1002/ajmg.b.32177
PATEL, S. et al. The Association Between Cannabis Use and Schizophrenia: Causative or Curative? A Systematic Review. Cureus, v. 12, n. 7, e9309, 2020. Disponível em: https://doi.org/10.7759/cureus.9309. DOI: https://doi.org/10.7759/cureus.9309
PROJETO DIRETRIZES. Associação Brasileira de Psiquiatria Sociedade Brasileira de Cardiologia. Abuso e Dependência de Maconha. 2012. Disponível em: http://www.projetodiretrizes.org.br/diretrizes11/abuso_e_depend%C3%83%C2%AAncia_de_maconha.pdf.
RANG, H.P. et al. Rang & Dale’s Pharmacology. 10 ed, 760p. Elsevier Health Sciences, 2023.
RANGANATHAN, M. et al. Naltrexone does not attenuate the effects of intravenous Δ9-tetrahydrocannabinol in healthy humans. International Journal of Neuropsychopharmacology, v. 15, n. 9, p. 1251-1264, 2012. Disponível em: https://doi.org/10.1017/S1461145711001830. DOI: https://doi.org/10.1017/S1461145711001830
RIGONI, M. dos S.; DA SILVA OLIVEIRA, M.; ANDRETTA, I. Consequências neuropsicológicas do uso da maconha em adolescentes e adultos jovens. Ciências & Cognição, v. 8, p. 118-126, 2006. Disponível em: https://pepsic.bvsalud.org/pdf/cc/v8/v8a13.pdf.
SKOSNIK, P. D. et al. Affect processing and positive syndrome schizotypy in cannabis users. Psychiatry Research, v. 157, n. 1-3, p. 279-282, 2008. Disponível em: https://doi.org/10.1016/j.psychres.2007.02.010. DOI: https://doi.org/10.1016/j.psychres.2007.02.010
SORKHOU, M.; BEDDER, R. H.; GEORGE, T. P. The Behavioral Sequelae of Cannabis Use in Healthy People: A Systematic Review. Frontiers in Psychiatry, v. 12, artigo 630247, p. 1-19, 2021, Disponível em: https://doi.org/10.3389/fpsyt.2021.630247. DOI: https://doi.org/10.3389/fpsyt.2021.630247
SOUSA, M. M.; SILVA, J. C. M. Associação entre o uso de cannabis e o desenvolvimento de transtornos psicóticos: uma revisão sistemática de literatura. Revista Perquirere, v. 20, n. 1, p. 08-24, 2023. Disponível em: https://revistas.unipam.edu.br/index.php/perquirere/article/view/3086.
WORLD Drug Report 2019. Unodc – United Nations Office on Drugs and Crime, 2019. Disponível em: https://wdr.unodc.org/wdr2019/prelaunch/pre-launchpresentation_WDR_2019.pdf.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Ana Eliza FURLAN, Mariane Poiati BATISTA, Mateus Ribeiro SATIN, Milena de Paula Farinelli LIMA, Regina de Souza PAPIS, Tafnes Antoniola BORGES (Autor)
This work is licensed under a Creative Commons Attribution 4.0 International License.
